Clozapine-Induced Gastrointestinal Hypomotility: A 22-Year Bi-National Pharmacovigilance Study of Serious or Fatal ‘Slow Gut’ Reactions, and Comparison with International Drug Safety Advice
نویسندگان
چکیده
منابع مشابه
Clozapine-Induced Gastrointestinal Hypomotility: A 22-Year Bi-National Pharmacovigilance Study of Serious or Fatal ‘Slow Gut’ Reactions, and Comparison with International Drug Safety Advice
INTRODUCTION Clozapine is the preferred antipsychotic for treatment-resistant schizophrenia, but has significant adverse effects, including gastrointestinal hypomotility or 'slow gut', which may result in severe constipation, ileus, bowel obstruction, and even death. These gastrointestinal effects remain inadequately recognized. METHODS We reviewed all reports of serious clozapine-induced gas...
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Available online 27 February 2016 serum levels and (3) that this hypomotilitywas not reported by patients by themeans of subjective constipation symptoms. Remarkably, CTTs in clozapine were four times longer than for other antipsychotics or population norms and 4 of 5 clozapine-treated patients showed clear Clozapine is still the most effective antipsychotic drug in the manhypomotility (Every-P...
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ژورنال
عنوان ژورنال: CNS Drugs
سال: 2017
ISSN: 1172-7047,1179-1934
DOI: 10.1007/s40263-017-0448-6